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Table 1 Activation and inhibition receptors of NK cells

From: Natural killer group 2D receptor and its ligands in cancer immune escape

Receptor

Ligand

Function

Reference

NKG2A/CD94

HLA-E

Inhibition

[11]

NKG2C/CD94

HLA-E

Activation

[11]

KIR2DL

HLA-A, HLA-B, HLA-C

Inhibition

[8,9,10]

KIR2DS

HLA-A, HLA-B, HLA-C

Activation

[8,9,10]

KIR3DL

HLA-A, HLA-B, HLA-C

Inhibition

[8,9,10]

KIR3DS

HLA-A, HLA-B, HLA-C

Activation

[8,9,10]

NKG2D

MICA\B, ULBP1–6

Activation

[21]

NKp30

n.d

Activation

[12]

NKp44

n.d

Activation

[12]

NKp46

n.d

Activation

[12]

  1. n.d not determined
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Molecular Cancer

ISSN: 1476-4598