Natural killer group 2D receptor and its ligands in cancer immune escape

Table 2 Molecules alter the expression of NKG2D on NK cells

Molecule	Mechanism	Function	Reference
PCLP1	Contact-dependent manner	↓	[23]
IDO	JNK pathway	↓	[24, 25]
PGE2	EP2/4, AC/cAMP/PKA pathway	↓	[26,27,28]
MIF	n.d	↓	[29,30,31]
TGF-β	n.d	↓	[32]
HIF-1	↑PGE2, TGF-β	↓	[37, 38]
IL-12	n.d	↑	[96]
IL-15	n.d	↑	[97]
IL-2	n.d	↑	[98]

ISSN: 1476-4598