Fig. 1

CircPSMC3 expression is down regulated in clinical GC specimens and cell lines. a Scatter plot analyses of circRNAs microarray data showing differentially expressed circRNA in lymph node metastasis group and normal group . High expression level is indicated by “red” and low levels by “green”. b Scatter plot analyses of circRNA microarray data showing differentially expressed circRNAs in lymph node metastasis group and no lymph node metastasis group. c GO analysis of circRNAs in lymph node metastasis group and normal group. d GO analysis of circRNAs in lymph node metastasis group and no lymph node metastasis group. e The spliced mature sequence length of circPSMC3 derived from the PSMC3 gene is 502 bp. f QRT-PCR for the abundance of circPSMC3 in GC cells treated with RNase R. g QRT-PCR for the abundance of PSMC3 mRNA in GC cells treated with RNase R. h CircPSMC3 expressions were evaluated using qRT-PCR in 106 pairs of gastric cancer plasmas and 21 pairs of normal plasmas. i CircPSMC3 expressions were measured using qRT-PCR in 106 pairs of gastric cancer (Tumor) and matched noncancerous tissue (Normal). j The expressions of circPSMC3 were evaluated in cell lines using qRT-PCR. k The area under the ROC curve (AUC) in distinguishing GC plasmas and normal ones was 0.9326. l Kaplan Meier survival curve showed the relationship between circPSMC3 and survival rates. **p < 0.01, ***p < 0.001