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Table 2 Genetic manipulation of exosome release in cancer cells

From: Mechanisms associated with biogenesis of exosomes in cancer

Gene Effect on exosome secretion Cancer cell type
RAB27A Knockdown decreases Cervical cancer cells (HeLa) [6] Breast cancer cells (4 T1 [44], TS/A [44], and MDA MB 231 [56,75]) Bladder cancer cells (T24 and FL3) [63] Head and neck squamous cell carcinoma cells (SCC61 [56, 76] and mEERL [67])
RAB27B Knockdown decreases Cervical cancer cells (HeLa) [6] Bladder cancer cells (T24 and FL3) [63] Head and neck squamous cell carcinoma cells (mEERL) [67]
PIKfyve Knockdown increases Prostate cancer cells (PC3) [74]
Hrs Knockdown decreases Head and neck squamous cell carcinoma cells (SCC61) [56]
Syt7 Knockdown decreases Head and neck squamous cell carcinoma cells (SCC61) [56]
Cortactin Knockdown increases, overexpression decreases Head and neck squamous cell carcinoma cells (SCC61) [76]
STAT3 Knockdown decreases Ovarian cancer cells (OVCAR8) [79]
PKM2 Knockdown decreases Lung (A549) and cervical cancer cells (HeLa) [83]
Munc13–4 Knockdown decreases Breast cancer cells (MDA MB 231) [96]
miR-155 Knockdown decreases, overexpression increases Pancreatic cancer cells (Panc1) [101]
EGFR Oncogenic EGFRvIII increases Glioma cells (U373) [39]
Ras Oncogenic HRas increases Intestinal epithelial cells (IEC-18) [37, 105]
hnRNP H1 Knockdown decreases Prostate cancer cells (C4-2B) [66]
Liver Kinase B1 Expression restoration increases Lung cancer cells (H460 and A549) [107]
EIF3C Overexpression increases Liver cancer cells (PLC5, SNU449 and Huh7) [64]