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Table 1 Extracellular vesicles miRNA cargo and chemoresistance in different cancers

From: Extracellular vesicles-mediated intercellular communication: roles in the tumor microenvironment and anti-cancer drug resistance

Cancer Anti-cancer drugs Cell lines miRNA cargo Mechanism Reference
Lung Cisplatin A549/A549-DDP ↓ miR-100-5p horizontal transfer [133]
Lung Gemcitabine A549/A549-GR ↑ miR-222-3p horizontal transfer [134]
Lung Cisplatin A549/H1299 ↑ miR-96 horizontal transfer [135]
Lung Cisplatin A549/A549-DDP ↓ miR-146a-5p horizontal transfer [136]
Breast Docetaxel MCF-7 ↑ miR-100, miR-222, miR-30a, miR-17 horizontal transfer [137]
Breast Tamoxifen MCF-7 ↑ miR-221/222 horizontal transfer [138]
Breast Cisplatin 17-AAG PU-H71 Hs578Ts ↓ miR-134 horizontal transfer [139]
Breast Doxorubicin Paclitaxel MCF-7/MDA-MB-231 ↑ miR-155 horizontal transfer [140]
Breast Docetaxel Epirubicin Gemcitabine MDA-MB-231/HMLE ↑ miR-1246 horizontal transfer [141]
Breast Adriamycin MCF-7/MCF-7-Adr ↑ miR-222 horizontal transfer [142]
Oral cavity Cisplatin HSC-3/HSC-3R SCC-9/SCC-9R ↑ miR-21 horizontal transfer [143]
Melanoma Vemurafenib (PLX4032) MML-1/MML-1R A375 PDX ↑ miR-211–5p Autocrine [144]
Glioblastoma Temozolomide SHG-44/U87MG ↑ miR-221 horizontal transfer [145]
Prostate Docetaxel 22Rv1/22Rv1RD DU145/DU145RD PC3/PC3RD ↓ miR-34a horizontal transfer [146]
Colon Fluorouracil (5-FU) DLD-1/DLD-1-5-FU ↑ miR-145, miR-34a expulsion [113]
Pancreas Gemcitabine Panc1/Panc1-GR ↑ miR-155 horizontal transfer [147]
Leukemia Imatinib K562/K562-G01 ↑ miR-365 horizontal transfer [148]
Leukemia Daunorubicin HL60/HL60AR ↑ miR-196, miR20a expulsion [114]