Table 1 Extracellular vesicles miRNA cargo and chemoresistance in different cancers

Lung

Cisplatin

A549/A549-DDP

↓ miR-100-5p

horizontal transfer

[133]

Lung

Gemcitabine

A549/A549-GR

↑ miR-222-3p

horizontal transfer

[134]

Lung

Cisplatin

A549/H1299

↑ miR-96

horizontal transfer

[135]

Lung

Cisplatin

A549/A549-DDP

↓ miR-146a-5p

horizontal transfer

[136]

Breast

Docetaxel

MCF-7

↑ miR-100, miR-222, miR-30a, miR-17

horizontal transfer

[137]

Breast

Tamoxifen

MCF-7

↑ miR-221/222

horizontal transfer

[138]

Breast

Cisplatin

17-AAG

PU-H71

Hs578Ts

↓ miR-134

horizontal transfer

[139]

Breast

Doxorubicin

Paclitaxel

MCF-7/MDA-MB-231

↑ miR-155

horizontal transfer

[140]

Breast

Docetaxel

Epirubicin

Gemcitabine

MDA-MB-231/HMLE

↑ miR-1246

horizontal transfer

[141]

Breast

Adriamycin

MCF-7/MCF-7-Adr

↑ miR-222

horizontal transfer

[142]

Oral cavity

Cisplatin

HSC-3/HSC-3R

SCC-9/SCC-9R

↑ miR-21

horizontal transfer

[143]

Melanoma

Vemurafenib

(PLX4032)

MML-1/MML-1R

A375

PDX

↑ miR-211–5p

Autocrine

[144]

Glioblastoma

Temozolomide

SHG-44/U87MG

↑ miR-221

horizontal transfer

[145]

Prostate

Docetaxel

22Rv1/22Rv1RD

DU145/DU145RD

PC3/PC3RD

↓ miR-34a

horizontal transfer

[146]

Colon

Fluorouracil

(5-FU)

DLD-1/DLD-1-5-FU

↑ miR-145, miR-34a

expulsion

[113]

Pancreas

Gemcitabine

Panc1/Panc1-GR

↑ miR-155

horizontal transfer

[147]

Leukemia

Imatinib

K562/K562-G01

↑ miR-365

horizontal transfer

[148]

Leukemia

Daunorubicin

HL60/HL60AR

↑ miR-196, miR20a

expulsion

[114]