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Fig. 1 | Molecular Cancer

Fig. 1

From: TAMing pancreatic cancer: combat with a double edged sword

Fig. 1

The emergence of M2 macrophages from monocytes. Various signaling molecules like M-CSF, CCL2 etc. and certain pathways like PI3Kγ/PTEN and RBPJ/Notch cascades are involved in M2 differentiation from monocytes. Therapeutic interventions like pexidartinib, carlumab and PF-04136309 can be used to block this differentiation

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