Fig. 1From: TAMing pancreatic cancer: combat with a double edged swordThe emergence of M2 macrophages from monocytes. Various signaling molecules like M-CSF, CCL2 etc. and certain pathways like PI3Kγ/PTEN and RBPJ/Notch cascades are involved in M2 differentiation from monocytes. Therapeutic interventions like pexidartinib, carlumab and PF-04136309 can be used to block this differentiationBack to article page