Fig. 2From: The roles of extracellular vesicles in gastric cancer development, microenvironment, anti-cancer drug resistance, and therapyFunctions of cancer derived EVs in GC progression and metastasis. The first general mechanism is that GC cells-derived EVs promote tumor cells growth and metastasis through overexpression of multiple proteins, miRNAs and LncRNAs. The second general mechanism is that metastasis, including lymphtic, peritoneal, and liver-specific metastasis, which can be induced by tumor-derived EVs via different pathways in GC. Abbreviations: EGFR, epidermal growth factor receptorBack to article page