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Fig. 3 | Molecular Cancer

Fig. 3

From: The roles of extracellular vesicles in gastric cancer development, microenvironment, anti-cancer drug resistance, and therapy

Fig. 3

The functional network of cancer derived EVs in GC microenvironment. GC cells-derived EVs promote angiogenesis via releasing miR-130a. Pericytes, MSCs, and fibroblasts absorbed EVs to induce CAFs transformation in tumor microenvironment through different pathway or miRNAs in cells. The functions of cancer cells-derived EVs in adipocytes differentiation. Different immune cells in tumor microenvironment can be affected by tumor-derived EVs. GC-derived EVs inhibit T cell immunity, polarize neutrophils to a pro-tumor phenotype, induce macrophages to release more proinflammatory factors and active Th17 to promote cancer progression. Abbreviations: GC, gastric cancer; MSC, mesenchymal stem cell; CAF, cancer-associated fibroblast

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