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Fig. 2 | Molecular Cancer

Fig. 2

From: mRNA-to-protein translation in hypoxia

Fig. 2

HIF regulation in normoxia and hypoxia. HIF╬▒: hypoxia-inducible factor alpha; PHD: prolyl hydroxylase domain enzyme; FIH: factor inhibiting HIF; Cdk2: Cyclin dependent kinase 2; O2: oxygen molecule; ARNT: aryl hydrocarbon receptor nuclear translocator; HRE: hypoxia response element; p300: protein 300; CBP: CREB-binding protein; RBM4: RNA-binding motif protein 4; eIF4E2: eukaryotic initiation factor 4E2; OH: hydroxyl group; P: phosphate group; mRNA: messenger RNA; Ub: ubiquitin

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