Fig. 3

mRNA-to-protein translation initiation in normoxia and hypoxia. tRNA-Meti: transfer ribonucleic acid charged with initiation methionine; Met: methionine; eIF4E: eukaryotic initiation factor 4E; eIF4F: eukaryotic initiation factor complex 4F; eIF2E: eukaryotic initiation factor 2E; 2α: eukaryotic initiation factor 2 subunit α; mTOR: mammalian target of rapamycin; O2: oxygen; 4E-BP: eukaryotic initiation factor 4E binding protein; P: phosphate; PERK: protein kinase R (PKR)-like endoplasmic reticulum kinase; HIF2α: hypoxia-inducible factor 2α; OH: hydroxyl group; mRNA: messenger ribonucleic acid; TP: target protein; RBM4: RNA binding motif protein 4; eIF4E2: eukaryotic initiation factor 4E2; rHRE: RNA hypoxia response element