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Table 1 EVs-related specific chemokines in tumor environment

From: Microvesicles and chemokines in tumor microenvironment: mediators of intercellular communications in tumor progression

Tumor type EVs type Content of chemokines Role of Evs References
Breast cancer MVs CCL5, CCR6 metastasis, proliferation and cancer cell-induced angiogenesis [5, 47]
Colorectal adenocarcinoma MVs CCR6, CX3CR1, CCL2 antiapoptotic effect on monocytes, AKT kinase activation,proliferation [38, 49]
Gastric cancer MVs CCR6 tumor progression [52]
Glioblastoma EVs CCR8, CCL18 proliferation and drug resistance [56]
Haemophilia A MVs CXCL8, CXCL10, CCL2 immunological profile [36]
Leukemia Apoptotic blebs CCR7, CCL19 immuno modulation [50]
  Exsomoes CCL3, CCL4, CXCR4 cell survival and drug resistance [74]
  MVs CXCR4, CCL12 cell survival [68]
Lung carcinoma MVs CCR6, CX3CR1, CXCR4 metastasis, antiapoptotic effect on monocytes, AKT kinase activation [38, 58]
  Exsomoes CCL2, CCL3, CCL4, CCL5, CCL20 antitumor immune response [51]
Lymphoma Exosomes CCL2, CCL7 macrophage recruitment [42]
Melanoma Exosomes CCL2, CCL3, CCL4, CCL5, CCL7, CCL20 macrophage recruitment, antitumor immune response [42, 51]
  MVs CCL2 inhibi ttumor proliferation [49]
Pancreatic adenocarcinoma MVs CCR6, CX3CR1, CCL2, CCL3, CCL4, CCL5, CXCL8 anti-apoptosis, AKT kinase activation, angiogenesis [38, 39]
Prostate cancer Oncosomes CXCL12 oncogenic signaling [23]
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Molecular Cancer

ISSN: 1476-4598