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Table 1 Correlation between the density of macrophages at invasive front and clinicopathologic parameters (n = 81)

From: Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis

Parameters n (%) CD68 expression CD163 expression
Low High P Low High P
Gender     0.855    0.893
Male 48 (59.3) 25 23   24 24  
Female 33 (40.7) 16 17   17 16  
Age, years     0.908    0.575
<60 39 (48.1) 20 19   21 18  
≥60 42 (51.9) 21 21   20 22  
Tumor site     0.908    0.742
Colon 42(51.9) 21 21   22 20  
Rectal 39 (48.1) 20 19   19 20  
Tumor size, cm     0.271    
<5 54 (66.7) 25 29   28 26 0.753
≥5 27 (33.3) 16 11   13 14  
Tumor grade     0.715    0.018
Poor 32 (39.5) 17 15   11 21  
Moderate/Well 49(60.5) 24 25   30 19  
LVI     0.734    0.005
Absence 45(55.6) 23 22   29 16  
Presence 36(44.4) 18 18   12 24  
PNI     0.582    0.320
Absence 43(53.1) 23 20   24 19  
Presence 38(46.9) 18 20   17 21  
TI     0.228    0.014
T1–2 12(14.8) 8 4   10 2  
T3–4 69(85.2) 33 36   31 38  
LNM     0.016    < 0.001
N0–1 53(65.4) 32 21   36 17  
N2–3 28(34.6) 9 19   5 23  
TNM stagea     0.096    0.011
I/II 42(51.9) 25 17   27 15  
III 39(48.1) 16 23   14 25  
CA19–9, U/mL     0.296    0.576
<37 57(70.4) 31 26   30 27  
≥37 24(29.6) 10 14   11 13  
CEA, ng/ml     0.689    0.939
<5 55(67.9) 27 28   28 27  
≥5 26(32.1) 14 12   13 13  
Overall 81(100.0) 41 40   41 40  
  1. Notes: aThe 8th edition of the AJCC Cancer Staging Manual; Boldface indicates P < 0.05
  2. Abbreviations: LVI lymphovascular invasion, PNI perineural invasion, TI tumor invasion, LNM lymph node metastasis, TNM tumor-node-metastasis, CA19–9 carbohydrate antigen 19–9, CEA carcinoembryonic antigen, CD68 cluster of differentiation 68, CD163 cluster of differentiation 163