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Table 2 Univariate and multivariate analyses of clinicopathologic parameters associated with recurrence-free survival and overall survival

From: Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis

Parameters Recurrence-free survival Overall survival
Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
HR 95% CI P HR 95% CI P HR 95% CI P HR 95% CI P
Gender (Female vs Male) 0.960 0.517–1.783 0.897     1.025 0.480–2.189 0.949    
Age (<60 years vs ≥60 years) 1.168 0.642–2.126 0.612     1.579 0.739–3.372 0.238    
Tumor site (Colon vs Rectal) 0.753 0.412–1.375 0.355     0.644 0.302–1.376 0.256    
Tumor size (<5 cm vs ≥ 5 cm) 0.816 0.431–1.546 0.534     0.586 0.249–1.381 0.222    
Tumor grade (Well & Moderate vs Poor) 0.627 0.424–0.927 0.019 0.883 0.593–1.315 0.540 0.586 0.354–0.967 0.037 0.757 0.453–1.266 0.289
LVI (Presence vs Absence) 2.756 1.477–5.143 0.001 1.495 0.757–2.954 0.247 2.570 1.185–5.572 0.017 1.284 0.540–3.051 0.572
PNI (Presence vs Absence) 1.893 1.032–3.471 0.039 2.193 1.136–4.233 0.019 2.441 1.125–5.294 0.024 2.981 1.262–7.039 0.013
TI (T3–4 vs T1–2) 1.977 1.228–3.182 0.005 1.569 0.833–2.955 0.163 2.634 1.375–5.049 0.004 1.759 0.778–3.977 0.175
LNM (N2–3 vs N0–1) 1.967 1.406–2.753 < 0.001 1.155 0.627–2.127 0.644 2.084 1.380–3.147 < 0.001 0.891 0.410–1.935 0.770
TNM stagea (III vs II vs I) 4.070 2.172–7.629 < 0.001 2.409 0.793–7.317 0.121 8.401 2.964–23.811 < 0.001 7.113 1.505–33.627 0.013
CA19–9 (≥37 U/ml vs < 37 U/mL) 1.609 0.866–2.988 0.132     1.214 0.549–2.684 0.631    
CEA (≥5 ng/ml vs < 5 ng/ml) 1.331 0.716–2.471 0.366     1.464 0.685–3.126 0.325    
Tumor invasive front (High vs Low)             
CD68 1.653 0.091–3.033 0.105     1.571 0.743–3.322 0.237    
CD163 2.861 1.523–5.376 0.001 2.144 1.016–4.523 0.045 4.149 1.761–9.776 0.001 3.234 1.176–8.889 0.023
Non-tumor invasive front (High vs Low)             
CD68 1.515 0.825–2.781 0.180     1.364 0.645–2.884 0.416    
CD163 1.231 0.676–2.242 0.498     1.916 0.884–4.152 0.100    
  1. Notes: aThe 8th edition of the AJCC Cancer Staging Manual; Boldface indicates P < 0.05
  2. Abbreviations: LVI lymphovascular invasion, PNI perineural invasion, TI tumor invasion, LNM lymph node metastasis, TNM tumor-node-metastasis, CA19–9 carbohydrate antigen 19–9, CEA carcinoembryonic antigen, CD68 cluster of differentiation 68, CD163 cluster of differentiation 163