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Table 2 Univariate and multivariate analyses of clinicopathologic parameters associated with recurrence-free survival and overall survival

From: Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis

Parameters

Recurrence-free survival

Overall survival

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

HR

95% CI

P

HR

95% CI

P

HR

95% CI

P

HR

95% CI

P

Gender (Female vs Male)

0.960

0.517–1.783

0.897

   

1.025

0.480–2.189

0.949

   

Age (<60 years vs ≥60 years)

1.168

0.642–2.126

0.612

   

1.579

0.739–3.372

0.238

   

Tumor site (Colon vs Rectal)

0.753

0.412–1.375

0.355

   

0.644

0.302–1.376

0.256

   

Tumor size (<5 cm vs ≥ 5 cm)

0.816

0.431–1.546

0.534

   

0.586

0.249–1.381

0.222

   

Tumor grade (Well & Moderate vs Poor)

0.627

0.424–0.927

0.019

0.883

0.593–1.315

0.540

0.586

0.354–0.967

0.037

0.757

0.453–1.266

0.289

LVI (Presence vs Absence)

2.756

1.477–5.143

0.001

1.495

0.757–2.954

0.247

2.570

1.185–5.572

0.017

1.284

0.540–3.051

0.572

PNI (Presence vs Absence)

1.893

1.032–3.471

0.039

2.193

1.136–4.233

0.019

2.441

1.125–5.294

0.024

2.981

1.262–7.039

0.013

TI (T3–4 vs T1–2)

1.977

1.228–3.182

0.005

1.569

0.833–2.955

0.163

2.634

1.375–5.049

0.004

1.759

0.778–3.977

0.175

LNM (N2–3 vs N0–1)

1.967

1.406–2.753

< 0.001

1.155

0.627–2.127

0.644

2.084

1.380–3.147

< 0.001

0.891

0.410–1.935

0.770

TNM stagea (III vs II vs I)

4.070

2.172–7.629

< 0.001

2.409

0.793–7.317

0.121

8.401

2.964–23.811

< 0.001

7.113

1.505–33.627

0.013

CA19–9 (≥37 U/ml vs < 37 U/mL)

1.609

0.866–2.988

0.132

   

1.214

0.549–2.684

0.631

   

CEA (≥5 ng/ml vs < 5 ng/ml)

1.331

0.716–2.471

0.366

   

1.464

0.685–3.126

0.325

   

Tumor invasive front (High vs Low)

            

CD68

1.653

0.091–3.033

0.105

   

1.571

0.743–3.322

0.237

   

CD163

2.861

1.523–5.376

0.001

2.144

1.016–4.523

0.045

4.149

1.761–9.776

0.001

3.234

1.176–8.889

0.023

Non-tumor invasive front (High vs Low)

            

CD68

1.515

0.825–2.781

0.180

   

1.364

0.645–2.884

0.416

   

CD163

1.231

0.676–2.242

0.498

   

1.916

0.884–4.152

0.100

   
  1. Notes: aThe 8th edition of the AJCC Cancer Staging Manual; Boldface indicates P < 0.05
  2. Abbreviations: LVI lymphovascular invasion, PNI perineural invasion, TI tumor invasion, LNM lymph node metastasis, TNM tumor-node-metastasis, CA19–9 carbohydrate antigen 19–9, CEA carcinoembryonic antigen, CD68 cluster of differentiation 68, CD163 cluster of differentiation 163
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Molecular Cancer

ISSN: 1476-4598