Fig. 4

MiR155-mediated CD8+T cell apoptosis was counteracted by PD-1/PD-L1 blockade. a CD8+T cells percentage remained constant (left panel) and CD8+T cell apoptosis was not detected (right panel) upon treatment with anti-PD-L1 antibody and anti-PD-1 antibody in the co-culture system of miR155 inhibitor-transfected Farage cells. b CD8+T cells percentage was significantly increased (left panel) and CD8+T cell apoptosis was inhibited (right panel) upon treatment with anti-PD-L1 antibody and anti-PD-1 antibody in the co-culture system of miR155 mimics-transfected DB cells. c and d Farage cell viability remained unchanged in miR155 inhibitor-transfected Farage cells co-culture system treated with anti-PD-L1 and anti-PD-1 antibody (c), DB cell viability was obviously reduced by miR155 mimics-transfected DB cells co-culture system treated with anti-PD-L1 and anti-PD-1 antibody (d)