Fig. 4

Pvt1 knockdown reduces the ability of G-MDSCs to accelerate tumor progression and inhibit antitumor immune responses. Two groups of mice were given a s.c. injection of a mixture of LLCs and G-MDSCs transfected with si-Pvt1 (si-Pvt1 group) or si-NC (si-NC group). a Tumor volume was measured at the indicated time. b, c The proportions of CD8⁺IFN-γ⁺ CTLs and CD4⁺IFN-γ⁺ Th1 cells from draining lymph nodes, spleens and tumor tissues were analyzed via flow cytometry. **p < 0.01, and *p < 0.05