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Fig. 4 | Molecular Cancer

Fig. 4

From: Long noncoding RNA Pvt1 regulates the immunosuppression activity of granulocytic myeloid-derived suppressor cells in tumor-bearing mice

Fig. 4

Pvt1 knockdown reduces the ability of G-MDSCs to accelerate tumor progression and inhibit antitumor immune responses. Two groups of mice were given a s.c. injection of a mixture of LLCs and G-MDSCs transfected with si-Pvt1 (si-Pvt1 group) or si-NC (si-NC group). a Tumor volume was measured at the indicated time. b, c The proportions of CD8+IFN-γ+ CTLs and CD4+IFN-γ+ Th1 cells from draining lymph nodes, spleens and tumor tissues were analyzed via flow cytometry. **p < 0.01, and *p < 0.05

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