Fig. 5From: Neddylation: a novel modulator of the tumor microenvironmentNeddylation pathway plays a crucial role in the modulation of TME. 1) Neddylation inhibition suppresses the activation of tumor-associated fibroblasts (CAFs) and tumor-associated endothelial cells (CAEs). 2) Neddylation inhibition suppresses immune cells, including T cells, dendritic cells and macrophagesBack to article page