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Fig. 1 | Molecular Cancer

Fig. 1

From: The role of extracellular vesicles from different origin in the microenvironment of head and neck cancers

Fig. 1

Biogenesis and characteristics of EVs. a Exosomes are endosome-derived vesicles that result from the dynamic equilibrium of membrane regeneration and degradation via the endosomal sorting complex required for transport (ESCRT) complex and its associated accessory proteins (ALIX, VPS4, and TSG101) or nSMase and CD63. Early endosomes inwardly regenerate to form intraluminal vesicles (ILVs) or exosome structures and then mature to multivesicular bodies (MVBs) or multivesicular endosomes (MVEs). RAB GTPases guide the intracellular binding and transport of MVB(E)s. Exosomes can be secreted by the fusion of MVB(E)s with cell membranes or be degraded in lysosomes and autophagosomes. b Microvesicles derive directly from the budding or shedding of the plasma membrane (PM) via ESCRT, AFR6 or external stress

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Molecular Cancer

ISSN: 1476-4598