Fig. 2

Possible mechanism of exo-circRNAs. a Some exo-circRNAs are bind to miRNAs in exosome. After entering target cells, miRNAs are relaesed and target genes can be silenced. b When exo-circRNAs are not bind to miRNAs in exosmes, they are able to sponge spcific miRNAs in target cells. As a result, target genes are acivated