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Fig. 3 | Molecular Cancer

Fig. 3

From: Tumor endothelial cell-derived cadherin-2 promotes angiogenesis and has prognostic significance for lung adenocarcinoma

Fig. 3

Aberrantly increased CDH2 protein expression in ADC-derived ECs by IHC analysis in 218 tumor tissues from lung cancer patients (141 with ADC and 77 with SCC). a IHC images of heterogenous CDH2 localization and CDH2 expression scores for cancer cells from SCC and ADC samples. IHC staining for SCC and ADC cancer cells was scored by PP × IS. CDH2 expression localization in cancer cells was further rescored by the intensity of staining (IS, score: 0~3) in membrane, cytoplasm and nucleus. b, c High CDH2 expression in TECs from ADC tissues. The significantly positive relationship between CDH2 expression and tumor stage, as well as typical IHC images displaying increased CDH2 expression during tumor progression are shown. Microvessels are indicated with black arrow, based on positive staining for CD105. d The overall survival of patients with lung cancer and differential CDH2 expression in TECs. The prognostic value of CDH2 expression was investigated in 139 of 218 patients with lung cancer with respect to survival information

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