Fig. 1From: The interplay of circulating tumor DNA and chromatin modification, therapeutic resistance, and metastasisThe clinic applications of ctDNA include (1) ctDNA to identify mutations of interest (including resistance mutations), (2) early detection of disease recurrence in minimal residual disease, and (3) early detection of primary disease. (4) Identification of genetic determinants for targeted therapy. (5) Serial ctDNA quantification to assess tumor burden. (6) Reflection of tumor metabolic biologyBack to article page