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Fig. 6 | Molecular Cancer

Fig. 6

From: A positive feed-forward loop between LncRNA-URRCC and EGFL7/P-AKT/FOXO3 signaling promotes proliferation and metastasis of clear cell renal cell carcinoma

Fig. 6

FOXO3 inhibits URRCC level via binding to its promoter region. a: ChIP assay showing FOXO3 can bind to potential binding site on the URRCC promoter. b: A schematic illustration of FOXO3 binding element mutation on the URRCC promoter. c:Relative luciferase activity of the indicated promoter vectors in A498 cells transfected with Renilla luciferase plasmids. d: Representative FOXO3 IHC staining of ccRCC tissues compared to paired normal renal tissues (200×, 400×). e: Kaplan–Meier analyses of the correlations between FOXO3 expression and overall survival of 530 ccRCC patients from TCGA KIRC dataset. Log-rank test was used to calculate p values

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