From: Exosomes in gastric cancer: roles, mechanisms, and applications
Cargo type | Exosomal cargo | Originated cells | Recipient cells | Function | Reference |
---|---|---|---|---|---|
Protein | BMPs | SGC-7901 | Pericytes | Induce transition into cancer-associated fibroblasts | [45] |
EGFR | SGC-7901 | Primary mouse liver cells | Promote gastric cancer liver metastasis | [46] | |
TGF-β1 | Plasma from GC patients | CD4+CD45RA+ naïve T cells | Induce Treg cell differentiation | [43] | |
TGF-β | SGC-7901 and HGC-27 | HucMSCs | Trigger differentiation to carcinoma-associated fibroblasts | [44] | |
HMGB1 | BGC-823, HGC-27, MGC-803, and SGC-7901 | Neutrophils | Induce autophagy and pro-tumor activation | [8] | |
GKN1 | HFE-145 | AGS and MKN1 | Inhibit gastric tumorigenesis | [47] | |
CagA | CagA-expressing WT-A10 | WT-10 and AGS | Involved in the development of extragastric disorders associated with CagA-positive H. pylori infection | [48] | |
Apolipoprotein E | TAM | MFC and MGC-803 | Promote cell migration | [49] | |
MET | H. pylori-infected AGS | TAM | Promoted tumor growth and progression | [50] | |
UBR2 | p53−/−mBMMSC | p53+/+ mBMMSC and MFC | Promote cell proliferation, migration, and stemness | [51] | |
TRIM3 | Overexpressed MGC-803 and SGC-7901 | MGC-803 and SGC-7901 | Suppress gastric cancer growth and metastasis | [52] | |
miRNA | let-7 miRNA | AZ-P7a | / | Maintain cell malignance | [56] |
miR-423-5p | Overexpressed SGC-7901 and HGC-27 | SGC-7901 and HGC-27 | Promote cancer growth and metastasis | [54] | |
miR-155-5p | Paclitaxel-resistant MGC-803R | Paclitaxel-sensitive MGC-803S | Promote EMT transition and chemoresistance | [55] | |
miR-130a | SGC-7901 | HUVECs | Promote angiogenesis and tumor growth | [57] | |
miR-27a | SGC-7901 | CCC-HSF-1 | Promote transformation into cancer-associated fibroblasts | [23] | |
miR-451 | MKN45 | Th17 | Increase Th17 differentiation | [58] | |
miR-21-5p | MGC-803, MKN-45, HGC-27, and SGC-7901 | PMC and HMrSV5 | Induce MMT and promote tumor peritoneal metastasis | [59] | |
miR-21 | TAM | BGC-823 | Contributes to cell proliferation | [60] | |
miR-21 | TAM | MFC and MGC-803 | Confer cisplatin resistance | [61] | |
miR-221 | GC-MSC | HGC-27 | Promote cell proliferation and migration | [62] | |
miR-221 | BM-MSCs | BGC-823 and SGC-7901 | Enhance cell proliferation, migration, invasion, and adhesion to the matrix | [63] | |
lncRNA | ZFAS1 | BGC-823 | MKN-28 | Enhance cell proliferation and migration | [64] |
circRNA | ciRS-133 | SGC-7901 | 3T3L1 | Promote differentiation into brown-like cells | [68] |