Table 1 CircRNAs involved in the hallmarks of cancer

Sustaining growth signaling

CDR1as

NSCLC

up

TNM stage, lymph nodes metastasis and survival time

promote cell vitalities and growth, inhibit apoptosis and cell cycle arrest

miR-7/EGFR, CCNE1, PIK3CD.

[72]

CDR1as

CRC

up

advanced tumor stage, tumor depth, and survival time

–

miR-7/EGFR, RAF1

[73]

CDR1as

HCC

down

–

promote cell growth, adhesion, and inhibit migration

miR-7/EGFR

[74]

circHIPK3

CRC

up

metastasis, clinical stage and survival time

inhibite cell proliferation, migration, invasion, and induce apoptosis

miR-7/EGFR, FAK, IGF1R, YY1

[75]

hsa_circ_0046701

glioma

up

–

promote cell proliferation and invasion

miR-142-3p/ITGB8

[80]

circ-FBXW7

glioblastoma

down

survival time

inhibit cell proliferation and cell cycle acceleration

FBXW7-185aa/c-Myc

[52]

Circ-Amotl1

–

up

–

promote cell proliferation

c-myc

[84]

Evading growth inhibitors

circ-ITCH

Bca

down

histological grade and survival time

inhibite cell proliferation, migration, invasio, induce G1/S cell cycle arrest and apoptosis

miR-17, miR-224/p21, PTEN axis

[90]

circ-ZFR

GC

down

–

inhibit cell propagation, cell cycle and promote apoptosis

miR-130a, miR-107/PTEN

[91]

CDR1as

GC

up

lymph nodes metastasis and survival time

promote cell proliferation, migration and inhibit apoptosis

miR-7/PTEN/PI3K/AKT

[92]

circRNA-000425

GC

down

–

inhibit cell growth

miR-17,miR-106/p21, BIM

[93]

Circ100284

–

up

–

promote cell cycle acceleration

miR-217/EZH2/cyclin D1, CDK4

[97]

hsa_circ_0016788

HCC

up

–

promote cell proliferation, invasion and inhibit apoptosis

miR-486/CDK4 axis

[98]

circHIPK3

gallbladder cancer

up

–

promote cell survival and proliferation, inhibit cell apoptosis

miR-124/ROCK1, CDK6

[99]

Resisting apoptosis

hsa_circ_0007534

CRC

up

tumor stage and lymph node metastasis

ptomote cell proliferation and inhibit apoptosis

Bcl-2, Bax

[104]

circUBAP2

osteosarcoma

up

tumor progression and prognosis

promote cell growth and inhibit apoptosis

miR-143/Bcl-2

[105]

hsa_circ_0009910

osteosarcoma

up

–

promote cell proliferation inhibition, inhibit cell cycle arrest, and inhibit apoptosis

miR-449a/IL6R/Bcl-2/Bax

[106]

hsa_circRNA_103809

CRC

down

–

promote apoptosis

miR-532-3p/FOXO4 axis

[107]

circNFIX

glima

up

–

promote cell propagation, migration and inhibit apoptosis

miR-34a-5p/NOTCH1

[108]

circ-DNMT1

BC

up

–

inhibit autophagy, promote cell proliferation and survival

p53, AUF1

[110]

Uncontrolled replicative immortality

has-circ-0020397

CRC

up

–

promote cell viability and inhibit apoptosis

mir-138/TERT, PD-L1

[114]

Promoting angiogenesis

circRNA-MYLK

Bca

up

pathological stage, T and N classifications and survival time

promote cell growth, angiogenesis and metastasis

miR-29a/VEGFA/VEGFR2

[118]

cZNF292

Glima

up

–

promote cell proliferation, tube formation and angiogenic potential

VEGF-A, EGF, TGF-β1

[122]

circHIPK3

Bca

down

tumor grade, invasion, lymph node metastasis

inhibit migration, invasion, and angiogenesis

miR-558/HPSE/VEGF

[119]

Activating invasion and metastasis

circ-10,720

HCC

up

Tumor metastasis and survival time

promote cell proliferation, migration, invasion and EMT

Vimentin

[129]

circPTK2

NSCLC

down

–

inhibit cell invasion and EMT

miR-429, miR-200b-3p/TIF1y

[132]

circSMAD2

HCC

down

–

inhibit cell migration, invasion, and EMT

miR-629

[137]

hsa_circ_0061140

ovarian cancer

up

–

promote cell proliferation, migration, invasion and EMT

miR-370/FOXM1

[141]

circ_0067934

NSCLC

up

TNM stage, lymph node statu, distant metastasis and survival time

promote cell proliferation, migration, invasion and EMT

N-cadherin, vimentin snail, and E-cadherin

[142]

circRNA_0023642

GC

up

–

pormote cell proliferation, migration, invasion and EMT

N-cadherin, vimentin snail, and E-cadherin

[143]`