Fig. 8
From: RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3
Working model. The oncogenic role of FTO as an m6A demethylase in breast cancer. In FTO low expressed cells, BNIP3 mRNA is m6A methylated at the 3’UTR and up-regulation of BNIP3 induces apoptosis. While in FTO high expression cells, FTO mediates m6A demethylation of BNIP3 to cause its down-regulation, thus promoting cell proliferation. FTO-m6A-BNIP3 signal pathway is considered as a potential therapeutic target for breast cancer therapy