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Fig. 2 | Molecular Cancer

Fig. 2

From: Circular RNA circ-DONSON facilitates gastric cancer growth and invasion via NURF complex dependent activation of transcription factor SOX4

Fig. 2

circ-DONSON silencing suppresses GC cell proliferation, migration and invasion, and induces apoptosis. a qRT-PCR was performed to confirm the relative expression of circ-DONSON in BGC-823 and AGS cells transfected with two independent shRNAs targeting circ-DONSON. b-e CCK8, EdU, colony formation and Ki67 staining assays was used to analyze proliferation of BGC-823 and AGS cells after circ-DONSON silencing. f Annexin/PI staining followed by FACS analysis indicated that circ-DONSON knockdown induced apoptosis. g, h Transwell assay illustrated that circ-DONSON knockdown suppressed the migration and invasion of BGC-823 and AGS cells. i Western blotting analysis of N-cadherin and E-cadherin expression in BGC-823 and AGS cells after circ-DONSON depletion. *P < 0.05, **P < 0.01 and ***P < 0.001

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Molecular Cancer

ISSN: 1476-4598