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Fig. 6 | Molecular Cancer

Fig. 6

From: Circular RNA circ-DONSON facilitates gastric cancer growth and invasion via NURF complex dependent activation of transcription factor SOX4

Fig. 6

The NURF complex modulates GC progression. a BPTF and RBBP4 were upregulated in GC tissues according to TCGA database. b qRT-PCR analysis of expression levels of BPTF, RBBP4 and SNF2L in 142 GC tissues and adjacent normal tissues. c Relative expression of BPTF, RBBP4 and SNF2L in GC cell lines by qRT-PCR analysis. d-f CCK8, colony formation and EdU assays showed that knockdown of BPTF, RBBP4 or SNF2L suppressed proliferation of BGC-823 and AGS cells. g Knockdown of BPTF, RBBP4 or SNF2L promoted apoptosis of BGC-823 and AGS cells. h, i Transwell assay showed that knockdown of BPTF, RBBP4 or SNF2L inhibits migration and invasion of BGC-823 and AGS cells. **P < 0.01 and ***P < 0.001

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Molecular Cancer

ISSN: 1476-4598