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Table 1 Representative clinical trials of microbiota-linked for cancer

From: The microbiota and microbiome in pancreatic cancer: more influential than expected

Category Clinical Trial ID Therapeutic Agents/Intervention Study Phase Status Treatment Setting Primary Outcomes
Oral Microbiome and Pancreatic Cancer NCT03302637 Specimen Collection Observational Completed Pancreatic Cancer Compare bacterial taxa
Treatment of Patients with Cancer with Genetically Modified Salmonella Typhimurium Bacteria NCT00004988 VNP20009 I Completed Various Types Anti-tumor effect; maximum tolerated dose
Mixed Bacteria Vaccine (MBV) in Patients with Tumors Expressing NY-ESO-1 Antigen NCT00623831 Bacterial Vaccine I Completed Various Types Safety; pyrogenicity; immune responses; overall response
Probiotics in Colorectal Cancer Patients NCT00936572 Probiotics II Completed Colorectal Cancer Efficacy; immune response
Using Probiotics to Reactivate Tumor Suppressor Genes in Colon Cancer NCT03072641 Probiotics NA Completed Colon Cancer Microbiota composition and epigenetic changes
Safety & Immunogenicity of JNJ-64041809, a Live Attenuated Double-deleted Listeria Immunotherapy, in Participants with mCRPC NCT02625857 JNJ-64041809 I Completed Prostate Cancer Safety and toxicity; ORR; PFS
Safety & Immunogenicity of JNJ-64041757, Live-attenuated Double-deleted Listeria Immunotherapy, in Subjects With NSCLC NCT02592967 JNJ-64041757 I Active, not recruiting NSCLC Safety and toxicity; ORR; PFS
Effects of Chemotherapy on Intestinal Bacteria in Patients with Newly Diagnosed Breast Cancer NCT02370277 Specimen Collection Observational Active, not recruiting Breast Cancer Change in intestinal microbiota
Phase I/II Study of APS001F With Flucytosine and Maltose in Solid Tumor NCT01562626 APS001F I/II Recruiting Solid Tumor Safety and toxicity
Pembrolizumab With Intratumoral Injection of Clostridium Novyi-NT NCT03435952 Pembrolizumab Clostridium NovyiNT I Recruiting Solid Tumor Maximum tolerated dose; overall response
Engineering Gut Microbiome to Target Breast Cancer NCT03358511 Probiotics NA Recruiting Breast Cancer Mean number of CD8+ cells
Gut Microbiome & Gastrointestinal Toxicities as Determinants of Response to Neoadjuvant Chemo for Advanced Breast Cancer NCT02696759 Specimen Collection NA Recruiting Breast Cancer pCR
Microbiome in Lung Cancer and Other Malignancies NCT03688347 Specimen Collection Observational Recruiting Lung Cancer Compare bacterial taxa
MRx0518 and Pembrolizumab Combination Study NCT03637803 MRx0518 Pembrolizumab I Not yet recruiting Solid Tumor Safety and tolerability; anti-tumor effect