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Fig. 4 | Molecular Cancer

Fig. 4

From: A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling

Fig. 4

Silencing of circPPP1R12A impairs the cell proliferation, migration and invasion abilities of CC cells. a Schematic illustration of siRNA targeting the back-splice junction of circPPP1R12A and real-time PCR confirmation showing circPPP1R12A silencing in HCT-116 and LoVo cells. b CircPPP1R12A silencing impaired the proliferation of HCT-116 and LoVo cells shown by CCK8 assay. c CircPPP1R12A silencing impaired the proliferation of HCT-116 and LoVo cells shown by colony formation assay. d CircPPP1R12A silencing impaired the migration of HCT-116 and LoVo cells shown by wound healing assay. e CircPPP1R12A silencing impaired the invasion of HCT-116 and LoVo cells shown by matrigel assay. The data are represented as the means ± SEM; *P < 0.05, **P < 0.01

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