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Fig. 8 | Molecular Cancer

Fig. 8

From: A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling

Fig. 8

circPPP1R12A-73aa promotes the proliferation, migration and invasion abilities of CC via activating Hippo-YAP signaling pathway. a heatmap, generated from the RNA-seq analysis, showing differential gene expression between the indicated four groups. b Western Blot was used to evaluate the expression level of MST1, LAST1, YAP and TAZ. c The cell viability was analyzed by CCK8 assay to evaluate the YAP inhibition on the circPPP1R12A-73aa promoted proliferation. d The migration ability was analyzed by wound healing assay to evaluate the YAP inhibition on the circPPP1R12A-73aa promoted proliferation. e The invasion ability was analyzed by transwell assay to evaluate the YAP inhibition on the circPPP1R12A-73aa promoted proliferation. The data are represented as the means ± SEM; *P < 0.05. The red * indicated the Lv-flag-circPPP1R12A-WT group, The blue * indicated the Lv-circPPP1R12A-73aa group

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Molecular Cancer

ISSN: 1476-4598