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Fig. 7 | Molecular Cancer

Fig. 7

From: Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy

Fig. 7

KRA-533 inhibits mutant KRASG12D driven lung cancer growth in genetically engineered mouse model. (a) After administration of adenovirus Cre recombinase in KRASG12D mice for 10 weeks, mice were treated with KRA-533 (20 mg/kg/d) for four months (n = 8 each group). H&E images from control or treatment group are shown. (b) Tumor numbers were counted under the microscope and tumor area was quantified using Openlab modular imaging software. Data represent mean ± SD, n = 8 per group. **P < 0.01, by 2-tailed t test. (c) Survival of mice was calculated up to four months before euthanization in the control group versus the KRA-533 treatment group. Data represent mean ± SD, n = 8 per group. **P < 0.01, by 2-tailed t test

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