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Fig. 3 | Molecular Cancer

Fig. 3

From: Novel lncRNA-IUR suppresses Bcr-Abl-induced tumorigenesis through regulation of STAT5-CD71 pathway

Fig. 3

LncRNA-IUR overexpression sensitizes Abl transformant to undergo apoptosis and attenuates tumor growth in a xenograft mouse model. a, RT-PCR was performed to examine lncRNA-IUR expression in K562 cell lines overexpressing lncRNA-IUR-5, -6, -8 or empty vector (EV). b, Cell viability of indicated K562 cell lines was analyzed by flow cytometry after treatment with indicated concentrations of imatinib for 36 h (n = 3; means ± SEM; **p < 0.01). c, Nude mice were subcutaneously injected with indicated K562 cell lines. Shown were representative images of tumors excised from these nude mice. d, Analysis of lncRNA-IUR expression in indicated tumor lysates by quantitative real-time PCR (n = 3; means ± SEM; ***p < 0.001). e, RT-PCR was performed to examine the murine lncRNA-IUR expression in NS2 cell lines overexpressing lncRNA-IUR-m5, -m6, -m8 or EV. f, Cell viability of indicated NS2 cell lines was analyzed by flow cytometry after treatment with indicated concentrations of imatinib for 36 h (n = 3; means ± SEM; **p < 0.01). g, Shown were representative images of nude mice subcutaneously injected with indicated NS2 cell lines. h, Murine lncRNA-IUR expression in these tumor lysates was analyzed by quantitative real-time PCR (n = 3; means ± SEM; **p < 0.01)

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