Fig. 3

GBCDRlnc1 is upregulated in gallbladder cancer tissues and promotes chemoresistance of gallbladder cancer cells in vitro. a Relative expression of GBCDRlnc1 in gallbladder cancer tissues and neighboring noncancerous tissues was detected by qRT-PCR (P < 0.01, n = 45). b Kaplan–Meier method with the log-rank test was used to analyze the overall survival curves of patients in high and low GBCDRlnc1 expression groups (log-rank = 5.396, P < 0.05). c Relative expression of GBCDRlnc1 in Dox-resistant gallbladder cancer cells and their parental cells was determined by qRT-PCR. d The sensitivities of Dox-resistant gallbladder cancer cells under different transfection with Dox were determined by CCK-8 assay. e The sensitivities of Dox-resistant gallbladder cancer cells under different transfection with 5-FU were determined by CCK-8 assay. f The sensitivities of the parental gallbladder cancer cells under different transfection with Dox were determined by CCK-8 assay. g The sensitivities of the parental gallbladder cancer cells under different transfection with 5-FU were determined by CCK-8 assay. The mean ± SD of triplicate experiments were plotted, **P < 0.01, ***P < 0.001