Skip to main content
Fig. 5 | Molecular Cancer

Fig. 5

From: CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer

Fig. 5

FBXW7 and MOAP1 attenuate miR-92a-3p-mediated promotion of aggressiveness and chemotherapy resistance of CRC in vivo. a The formation of metastatic nodules in lung derived from SW620/Mock, SW620/miR-92a-3p, and SW620/miR-92a-3p/FBXW7 cells by tail vein injection method (n = 8 in each group). b The formation of metastatic nodules in liver derived from SW620/Mock, SW620/miR-92a-3p, and SW620/miR-92a-3p/FBXW7 cells by subcapsular injection of the spleen method (n = 8 in each group). c The formation of subcutaneous tumors derived from SW480/Mock, SW480/miR-92a-3p, and SW480/miR-92a-3p/FBXW7 cells under 5-FU/L-OHP therapy by subcutaneous injection into the flank of mice n = 6 in each group). d-f Detection of proliferation and apoptosis by Ki-67 d, TUNEL e, and caspase3 f expression in tumor tissues derived from SW480/Mock, SW480/miR-92a-3p, and SW480/miR-92a-3p/FBXW7 cells by IHC and TUNEL assays. g The formation of subcutaneous tumors derived from SW480/Mock, SW480/miR-92a-3p, and SW480/miR-92a-3p/MOAP1 cells under 5-FU/L-OHP therapy by subcutaneous injection into the flank of mice (n = 6 in each group). h-j Detection of proliferation and apoptosis by Ki-67 (H), TUNEL i, and caspase3 j expression in tumor tissues derived from SW480/Mock, SW480/miR-92a-3p, and SW480/miR-92a-3p/MOAP1 cells by IHC and TUNEL assays

Back to article page

Molecular Cancer

ISSN: 1476-4598