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Table 4 The main roles of the exemplified lncRNAs

From: Long non-coding RNAs in Oral squamous cell carcinoma: biologic function, mechanisms and clinical implications

LncRNA Molecular functions Mechanism
MALAT1 RNA splicing regulator Sponges miR-125b and promotes STAT3 expression.
CCAT1 miRNA sponge Sponges for miR-155-5p and let7b-5p.
MEG3 Transcriptional repressor Suppresses Tumor via Wnt/β-catenin signaling pathway.
NEAT1 Chromatin modification Downregulates miR-365 expression.
TUG1 miRNA sponge Promotes OSCC via TUG1/miR-219/FMNL2 axis.
UCA1 Transcriptional activator Promotes tumor invasion and metastasis possibly through Wnt/β-catenin signaling pathway.
Linc-RoR miRNA sponge Sponges for miR-145 to inhibit the expression levels of OCT4, NONOG and SOX2.