Table 4 The main roles of the exemplified lncRNAs
LncRNA | Molecular functions | Mechanism |
|---|---|---|
MALAT1 | RNA splicing regulator | Sponges miR-125b and promotes STAT3 expression. |
CCAT1 | miRNA sponge | Sponges for miR-155-5p and let7b-5p. |
MEG3 | Transcriptional repressor | Suppresses Tumor via Wnt/β-catenin signaling pathway. |
NEAT1 | Chromatin modification | Downregulates miR-365 expression. |
TUG1 | miRNA sponge | Promotes OSCC via TUG1/miR-219/FMNL2 axis. |
UCA1 | Transcriptional activator | Promotes tumor invasion and metastasis possibly through Wnt/β-catenin signaling pathway. |
Linc-RoR | miRNA sponge | Sponges for miR-145 to inhibit the expression levels of OCT4, NONOG and SOX2. |