Table 1 Summary of TAM receptor inhibitors in preclinical studies
TAM Targeting Drug (Drug Type) | Target(s) | Outcomes in cancer models |
|---|---|---|
2,4-diaminopyrimidine-5-carboxamide analogs (Small molecule) | Tyro3 | Not reported. |
“Compound 47” (Small molecule) | Tyro3, IGF-1R, EphA2 | Anti-cancer properties in HCC cell lines and xenograft models [158]. |
DP-3975 (Small molecule) | Axl | Anti-cancer properties in mesothelioma cell lines [131]. |
GL21.T (RNA aptamer) | Axl | Anti-cancer properties in a glioblastoma and a lung cancer cell line and mouse models [164]. |
Mer590 (Monoclonal antibody) | MerTK | Anti-cancer properties in lung cancer cell lines [157]. |
NPS-1034 (Small molecule) | Axl, Met | Anti-cancer properties in EGFR inhibitor resistant lung cancer cell lines and xenograft models [165]. |
Spiroindoline-based analogs (Small molecule) | Tyro3 | None reported. |
UNC569 (Small molecule) | MerTK, Axl, Tyro3 | Anti-cancer properties in ALL and AML cell lines [146, 147]. |
UNC1062 (Small molecule) | MerTK | Anti-cancer properties AML cell lines [147]. |
UNC1666 (Small molecule) | MerTK, Flt3 | Reduces colony formation in AML cell lines [148]. |
UNC2025 (Small molecule) | MerTK, Flt3 | Anti-cancer properties in non-small cell lung cancer, leukemia and glioblastoma mouse models [152,153,154,155]. |
UNC 2250 (Small molecule) | MerTK | Anti-cancer properties in mantle cell lymphoma cell lines and mouse models [166]. |
UNC2541 (Small molecule) | MerTK | None reported. |
YW327.6S2 (Monoclonal antibody) | Axl | Anti-cancer properties in lung and breast cancer mouse models [70]. |