Table 2 Summary of clinical trials targeting TAM receptor activity
TAM Targeting Drug (Drug Type) | Target(s) | Condition(s) | ClincialTrials.gov Identifier(s) |
|---|---|---|---|
AVB-S6–500 (Axl-Fc fusion protein) | Gas6 | Ovarian Cancer Epithelial Ovarian Cancer Primary Peritoneal Carcinoma Fallopian Tube Cancer | NCT03401528 NCT03607955 NCT03639246 |
ASLAN-002/BMS-777607 (Small molecule) | Met, RON, FLT3, Axl | Advanced or Metastatic Solid Tumors | NCT00605618 NCT01721148 [162] |
BA3011/CAB-AXL-ADC (Antibody-drug conjugate) | Axl | Solid Tumor Non-Small Cell Lung Cancer Castration-Resistant Prostate Cancer Pancreatic Cancer | NCT03425279 |
Bemcentinib/BGB324/R428 (Small molecule) | Axl | Advanced or Metastatic Solid Tumors | NCT02424617 NCT02488408 NCT02872259 NCT02922777 NCT03184558 NCT03184571 NCT03649321 NCT03654833 |
BPI-9016 M (Small molecule) | Axl, Met | Solid Tumors Non-Small Cell Lung Cancer | NCT02478866 NCT02929290 |
CCT301 (CAR-T) | Axl | Renal Cell Carcinoma | NCT03393936 |
INCB081776 (Small molecule) | Axl, MerTK | Advanced Solid Tumors | NCT03522142 |
MRX-2843 (Small molecule) | MerTK, FLT3 | Advanced or Metastatic Solid Tumors | NCT03510104 |
ONO-7475 (Small molecule) | Axl, MerTK | Advanced or Metastatic Solid Tumors Acute Leukemia | NCT03176277 NCT03510104 |
TP-0903 (Small molecule) | Axl | Advanced Solid Tumors Chronic Lymphocytic Leukemia Small Lymphocytic Lymphoma EGFR Positive Non-small Cell Lung Cancer Colorectal Carcinoma Recurrent Ovarian Carcinoma BRAF-Mutated Melanoma | NCT02729298 NCT03572634 |