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Fig. 7 | Molecular Cancer

Fig. 7

From: Circular RNA ACVR2A suppresses bladder cancer cells proliferation and metastasis through miR-626/EYA4 axis

Fig. 7

Overexpression of circACVR2A inhibits the growth and metastasis of BC cells in vivo. a-b UM-UC-3 cells stably transfected with circACVR2A or vector were injected subcutaneously into the left dorsum of BALB/c nude mice. Tumor volume and weight were dramatically decreased in circACVR2A overexpressing group. c HE staining and IHC analysis of EYA4 and ID2 expression in subcutaneous xenograft tumors. Overexpression of circACVR2A could up-regulate EYA4 and down-regulate ID2 expression. d Bioluminescence of the popliteal LNs was detected by an in vivo bioluminescence imaging system. e Popliteal LNs were enucleated and measured. The volume of popliteal LNs was significantly decreased in circACVR2A overexpressing group. f Representative images of HE staining analysis of the popliteal LNs in each group

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