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Fig. 7 | Molecular Cancer

Fig. 7

From: Lung adenocarcinoma-intrinsic GBE1 signaling inhibits anti-tumor immunity

Fig. 7

The summary and schematic diagram of this study. a STRING network analysis of GBE1 with CD8, PD-L1, CCL5, CXCL10, TMEM173, and IFNα/β pathway in the database. b Graphical abstract of this study. GBE1 blockade induces IFN-I production via STING signaling pathway, accompanied by upregulation of PD-L1 in LUAD cells, which further enhances the secretions of CCL5 and CXCL10 to recruit CD8+ T lymphocytes in the tumor microenvironment. Hence, suggesting that GBE1 may be a promising target to facilitate tumor rejection through cancer immunotherapy in LUAD

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