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Table 2 Expression of necroptotic factors in cancer and its influence on cancer prognosis

From: The role of necroptosis in cancer biology and therapy

Cancer Type Expression of Necroptotic Factors The Influence on Prognosis Reference
Breast Cancer decreased RIPK3 expression worse prognosis [7, 65]
Colorectal Cancer decreased RIPK3 expression; decreased MLKL expression reduced DFS and OS; reduced OS [12, 66, 67]
Acute Myeloid Leukemia decreased RIPK3 expression accelerated leukemogenesis and worse survival [11, 68]
Melanoma decreased RIPK3 expression;
decreased CYLD expression
not mentioned; enhanced tumor progression and metastasis [69, 70]
Head and Neck Squamous Cell Carcinoma decreased RIPK1 expression enhanced tumorigenesis [9]
Chronic Lymphocytic Leukemia decreased CYLD expression reduced OS [71]
Glioblastoma increased RIPK1 expression worse prognosis [10]
Lung Cancer increased RIPK1 expression promoted oncogenesis [72]
Pancreatic Cancer increased expression of RIPK1, RIPK3, FADD and MLKL promoted oncogenesis [64, 73]
Gastric Cancer decreased MLKL expression reduced OS [74]
Ovarian Cancer Decreased MLKL expression reduced OS [75]
Cervical Squamous Cell Carcinoma decreased MLKL expression reduced OS [76]