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Fig. 3 | Molecular Cancer

Fig. 3

From: Crosstalk between autophagy and epithelial-mesenchymal transition and its application in cancer therapy

Fig. 3

P53 signaling pathway regulated autophagy and EMT. Nucleus P53 promotes the up-regulation of autophagy by down-regulating PI3K/AKT/mTOR signaling and enhancing the expression of autophagy-related genes, including Ulk1/2, Atg4, Atg7, and Atg10. Nevertheless, P53 inhibits autophagy in the cytoplasm. The nucleus P53 reduced the expression of ZEB1, ZEB2, and SNAIL by activating the expression of miR-200a and miR-130b, resulting in EMT inhibition. Significantly, mutant P53 triggers EMT and mitochondrial fission that in turn strengthens autophagy

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