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Table 1 The translational application of autophagy inhibitors in anticancer therapy by regulating EMT

From: Crosstalk between autophagy and epithelial-mesenchymal transition and its application in cancer therapy

Autophagy Inhibitors Impair/Enhance EMT Mechanisms Cancer Types References
Chloroquine(CQ) Impair Reversing TGF-β-induced EMT Renal cell carcinoma(RCC) [6]
CQ Impair Down-regulating expression of vimentin and up-regulating expression of E-cadherin Nasopharyngeal carcinoma (NPC) [142]
CQ or 3-methyladenine (3-MA) Impair Inhibiting TGF-β1/Smad3-induced EMT Bladder cancer. [143]
3-MA Enhance Attenuating inhibitive effects of miR-16 mimics on TGF-β1-induced EMT Non-small cell lung carcinoma (NSCLC) [144]
3-MA Enhance Abolishing the sinomenine hydrochloride (SH) -mediated inhibition of vimentin, Snail and Slug expression Glioblastoma [145]