Skip to main content


Fig. 6 | Molecular Cancer

Fig. 6

From: The lncRNA UCA1 promotes proliferation, migration, immune escape and inhibits apoptosis in gastric cancer by sponging anti-tumor miRNAs

Fig. 6

knockdown of UCA1 expression inhibit the tumor growth in xenograft mouse model. a we examined the effect of knockdown of UCA1 on the regulation of subcutaneous transplantation mouse model of gastric cancer by using AGS cell line. The AGS-NC and AGS-UCA1-KD cells were injected subcutaneously into SCID mice. The tumor volumes were measured every week for 4 weeks. b the statistical analysis showed that knockdown of PDL1 expression significantly inhibits tumor growth. c after 28 days, the tumor weight of UCA1-KD group was lighter than that of control group (p < 0.001). d the qRT-PCR results showed that the level of miR-26a, miR-26b, miR-193a and miR-214 was increased in the UCA1-KD group. e the immunohistochemistry results showed that PDL1 protein level as well as Ki-67 was down regulated in UCA1-KD group. f The immunoblotting results showed that cleaved PARP1 and caspase-3 level was increased in the UCA1-KD tumors

Back to article page