Fig. 5

TERT^high/TERT^low -specific somatic mutation and somatic copy number alteration signatures. a Overview of genes with TERT^high/TERT^low -specific mutation signatures in LGG, LIHC and LUAD (FDR < 0.05). Samples are displayed as columns with the TERT^high/TERT^low label on the top, and different colors indicate different types of somatic mutations. The bar plots show the recalibrated mutation frequencies after propensity score weighting. b The genome-wide, TERT^high/TERT^low-specific focal amplification/deletion patterns in BRCA, LGG, LUAD, LIHC and SARC. The TERT^low-specific SCNA peaks are shown in turquoise, and the TERT^high-specific SCNA peaks are shown in tomato. The significant SCNA regions (FDR < 0.05) are indicated by the vertical blue dotted lines. The targets of FDA-approved drugs are highlighted in red. c Bar plot showing the top 5 enriched REACTOME pathways of TERT^high-specific mutated genes. Enrichment is represented as –log₁₀(P value). d Bar plot showing the top 5 enriched REACTOME pathways of TERT^high-specific amplified genes. Enrichment is represented as –log₁₀(P value)