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Fig. 2 | Molecular Cancer

Fig. 2

From: METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner

Fig. 2

Knockdown of METTL3 inhibited bladder cancer proliferation in vitro and in vivo. a and b. Knockdown of METTL3 inhibited cell proliferation as indicated by CCK-8 assays in EJ and T24 cells. c and d. Colony formation assay showed that METTL3 knockdown significantly decreased the cloning number of T24 and EJ cells compared with control group. The colony formation rate (colony number/ cells per well) is shown below the histogram. e and f. Cell cycle analyzed by flow cytometry. Histogram showed that METTL3 knockdown arrested at G1 phase in T24 and EJ cells. g. Representative image of the nude mice injected with T24 cells. h. Tumor weight and the tumor growth curve were measured in METTL3 knockdown cell and its control group. Data represented the mean ± SD from three independent experiments, *P < 0.05, **P < 0.01

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Molecular Cancer

ISSN: 1476-4598