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Fig. 3 | Molecular Cancer

Fig. 3

From: METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner

Fig. 3

Overexpression of METTL3 promoted bladder cancer proliferation in vitro and in vivo. a and b. Overexpression of METTL3 promoted cell proliferation as indicated by CCK-8 assays in EJ and T24 cells. c and d. Colony formation assay showed that METTL3 overexpression significantly increased the cloning number of T24 and EJ cells compared with control group. The colony formation rate (colony number/ cells per well) is shown below the histogram. e and f. Cell cycle analyzed by flow cytometry. Histogram showed that METTL3 overexpression decreased the percentage of G1 phase and increased the percentage of S phase. Data represented the mean ± SD from three independent experiments, *P < 0.05, **P < 0.01. g. Representative image of the nude mice injected with T24 cells. h. Tumor weight and the tumor growth curve were measured in METTL3 overexpression cells and its control group. Data represented the mean ± SD from three independent experiments, *P < 0.05, **P < 0.01

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Molecular Cancer

ISSN: 1476-4598