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Fig. 5 | Molecular Cancer

Fig. 5

From: METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner

Fig. 5

miR221 and miR222 rescued the proliferating function induced by METTL3 in bladder cancer cells. a and b. CCK8 assays were used to measure the effect of miR221/222 mimics or inhibitors on EJ and T24 cells with METTL3 knockdown and overexpression. miR221/222 mimics could rescue the cell growth inhibited by knockdown of METTL3 in EJ and T24 cells (a). The inhibitors of miR221/222 could partly reduced cell growth induced by overexpression of METTL3 in EJ and T24 cells (b). c and d. Colony formation assays showed that miR221/222 mimics could rescue the cell growth inhibited by knockdown of METTL3 in EJ and T24 cells. Data represented the mean ± SD from three independent experiments, *P < 0.05, **P < 0.01

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Molecular Cancer

ISSN: 1476-4598