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Table 1 Correlation between METTL3 expression and clinicopathological characteristics of 180 BCa patients

From: METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner

Parameters

Number of cases

METTL3 expression

P Value

Low

High

All cases

180

97

83

 

Age(years)

 <65

76

43

33

0.536

 ≥65

104

54

50

 

Gender

 Male

141

73

68

0.279

 Female

39

24

15

 

TNM stage

 pTa-pT1

116

64

52

0.642

 pT2-pT4

64

33

31

 

Histological grade

 Low

78

50

28

0.016a

 High

102

47

55

 

Tumor size(cm)

 <3

114

66

48

0.156

 ≥3

66

31

35

 
  1. aStatistically significant, P<0.05
  2. Notes: The total METTL3 immunostaining score was calculated as the sum of the score for the proportion of positively stained tumor cells (PP) and the score for staining intensity (SI) given by two pathologists blinded to the clinical parameters. PP was scored into four categories: 0 (< 5%, negative), 1 (5–25%, sporadic), 2 (25–50%, focal), 3 (> 51%, diffuse) and SI was scored on a scale of 0 to 3 (0, negative staining; 1, weak staining; 2, moderate staining; 3, strong staining). The final staining score was calculated by multiplying SI and PP score, resulting in a score value ranging from 0 to 9. The positive level of IHC staining was scored by two urologists and patients with different scores were divided into low- (0–3) and high-staining (4–9) groups