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Fig. 2 | Molecular Cancer

Fig. 2

From: Circular RNA circSLC8A1 acts as a sponge of miR-130b/miR-494 in suppressing bladder cancer progression via regulating PTEN

Fig. 2

Over-expression of circSLC8A1 inhibits the migration and invasion of bladder cancer cell. a The expression levels of circSLC8A1 and SLC8A1 mRNA in 5637 and T24 cells after transfection with circSLC8A1 or control vector plasmids were detected by qRT-PCR. b The effect of circSLC8A1 on cell migration capability was evaluated by wound healing assay in 5637 and T24 cells, respectively. c and d Cell migration and invasion abilities of 5637 and T24 cells transfected with circSLC8A1 or control vector were evaluated by transwell migration and matrigel invasion assays. e Two siRNAs specifically targeting circSLC8A1 were transfected into 5637 and T24 cells. The interfering efficacy of each siRNA on circSLC8A1 and SLC8A1 mRNA was tested by qRT-PCR. f The effect of si circSLC8A1–1 on cell migration capability was evaluated by wound healing assay in 5637 and T24 cells, respectively. g and h Cell migration and invasion abilities of 5637 and T24 cells transfected with si circSLC8A1–1 or siNC were evaluated by transwell migration and invasion assays. Data are mean ± SD, n = 3

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Molecular Cancer

ISSN: 1476-4598