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Fig. 5 | Molecular Cancer

Fig. 5

From: Circular RNA circSLC8A1 acts as a sponge of miR-130b/miR-494 in suppressing bladder cancer progression via regulating PTEN

Fig. 5

circSLC8A1 regulates PTEN expression and inhibits bladder cancer progression via targeting miR-130b and miR-494. a, b and c Transwell invasion and CCK-8 assays demonstrating that circSLC8A1 inhibited the invasion ability and proliferation of 5637 and T24 cells, and when co-transfected with miR-130b or miR-494, the inhibitory effect was reversed. d and e Western blot showed that miR-130b and miR-494 could partly decrease the protein expression level of PTEN which were promoted by circSLC8A1. f Western blot analysis of PTEN protein in 10 paired human bladder cancer specimens and normal adjacent tissue samples. Data are mean ± SD, n = 3

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