Table 1 Variety of positive rate of CTCs in HCC
From: Liquid biopsy in hepatocellular carcinoma: circulating tumor cells and circulating tumor DNA
Region | HCC patients | Background liver status | Methodology | Positive rate | Ref. |
|---|---|---|---|---|---|
China | 139 | HBVa: 85% LCb: 74% | CellSearch™ (Pre/post) | 43.9 % 54.0% | Yu et al [34], 2018 |
China | 112 | HBV: 75% | CanPatrol | 90.18% | Qi et al [35], 2018 |
Germany | 57 | CVHc:21% LC: 24% Alcohol: 7% NASHd: 10% | CellSearch™ | 15.8% | von Felden et al [36], 2017 |
United Kingdom | 69 | Alcohol: 32% NAFLDe:35% PBCf/AIHg:13% LC: 71% | ImageStream | 65.2% | Ogle et al [37], 2016 |
China | 36 | Not applicable | CTC-Chip | 100% | Zhang et al [38], 2016 |
China | 42 | HBV: 81%, HCVh: 2%, nonB, nonC: 17% | CTC-Chip | 59.5% | Wang et al [39], 2016 |
United States | 20 | HBV: 25%, HCV: 45% HBV and HCV: 10% Alcohol: 5% NAFLD: 10% | CellSearch™ | 40.0% | Kelley et al [40], 2015 |
South Korea | 81 | HBV: 80%, HCV: 11%, Alcohol: 4% LC: 59% | RT-PCRi (K19, CD44) | 22.2% | Choi et al [41], 2015 |
Egypt | 70 | HCV: 100% | Flow Cytometry (CK19, CD133, CD90) | 73% 69.5% 49.8% | Bahnassy et al [42], 2014 |
China | 299 | HBV: 90% LC: 90% | CellSearch™ | 42.6% | Guo et al [43], 2014 |
United Kingdom | 52 | Alcohol: 38%, HBV: 8% Diabetes: 12% | CellSearch™ ISETj | 28% 100% | Morris et al [44], 2014 |
China | 42 | LC: 55% | CellSearch™ | 52.3% | Fang et al [45], 2014 |
China | 27 | Not applicable | CellSearch™ | 88.9% | Li et al [46], 2013 |
Germany | 59 | Alcohol: 38%, HBV: 17%, HCV: 13% LC: 89% | CellSearch™ | 30.5% | Schulze et al [47], 2013 |
China | 123 | HBV: 75% LC: 76% | CellSearch™ | 66.6% | Sun et al [48], 2013 |
China | 60 | HBV: 93% LC: 93% | Flow cytometry | 50.0% | Liu et al [49], 2013 |
China | 85 | HBV: 84%, HCV: 7%, HBV and HCV: 5%, nonB, nonC: 4% | CellSearch™ | 81.0% | Xu et al [50], 2011 |
China | 82 | HBV: 80% | CellSearch™ | 68.3% | Fan et al [51], 2011 |
France | 44 | LC: 89% | ISET | 52.2% | Vona et al [52], 2004 |
China | 30 | HBV:100%, LC: 100% | RT-PCR (MAGE1/3) | 43.3% | Mou et al [53], 2002 |