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Table 1 Variety of positive rate of CTCs in HCC

From: Liquid biopsy in hepatocellular carcinoma: circulating tumor cells and circulating tumor DNA

Region HCC patients Background liver status Methodology Positive rate Ref.
China 139 HBVa: 85%
LCb: 74%
CellSearch™ (Pre/post) 43.9 %
54.0%
Yu et al [34], 2018
China 112 HBV: 75% CanPatrol 90.18% Qi et al [35], 2018
Germany 57 CVHc:21%
LC: 24%
Alcohol: 7%
NASHd: 10%
CellSearch™ 15.8% von Felden et al [36], 2017
United Kingdom 69 Alcohol: 32%
NAFLDe:35%
PBCf/AIHg:13%
LC: 71%
ImageStream 65.2% Ogle et al [37], 2016
China 36 Not applicable CTC-Chip 100% Zhang et al [38], 2016
China 42 HBV: 81%,
HCVh: 2%,
nonB, nonC: 17%
CTC-Chip 59.5% Wang et al [39], 2016
United States 20 HBV: 25%, HCV: 45%
HBV and HCV: 10%
Alcohol: 5%
NAFLD: 10%
CellSearch™ 40.0% Kelley et al [40], 2015
South Korea 81 HBV: 80%,
HCV: 11%,
Alcohol: 4%
LC: 59%
RT-PCRi (K19, CD44) 22.2% Choi et al [41], 2015
Egypt 70 HCV: 100% Flow Cytometry (CK19, CD133, CD90) 73%
69.5%
49.8%
Bahnassy et al [42], 2014
China 299 HBV: 90%
LC: 90%
CellSearch™ 42.6% Guo et al [43], 2014
United Kingdom 52 Alcohol: 38%,
HBV: 8%
Diabetes: 12%
CellSearch™
ISETj
28%
100%
Morris et al [44], 2014
China 42 LC: 55% CellSearch™ 52.3% Fang et al [45], 2014
China 27 Not applicable CellSearch™ 88.9% Li et al [46], 2013
Germany 59 Alcohol: 38%,
HBV: 17%,
HCV: 13%
LC: 89%
CellSearch™ 30.5% Schulze et al [47], 2013
China 123 HBV: 75%
LC: 76%
CellSearch™ 66.6% Sun et al [48], 2013
China 60 HBV: 93%
LC: 93%
Flow cytometry 50.0% Liu et al [49], 2013
China 85 HBV: 84%,
HCV: 7%,
HBV and HCV: 5%,
nonB, nonC: 4%
CellSearch™ 81.0% Xu et al [50], 2011
China 82 HBV: 80% CellSearch™ 68.3% Fan et al [51], 2011
France 44 LC: 89% ISET 52.2% Vona et al [52], 2004
China 30 HBV:100%,
LC: 100%
RT-PCR (MAGE1/3) 43.3% Mou et al [53], 2002
  1. aHepatitis B Virus
  2. bLiver cirrhosis
  3. cChronic viral hepatitis
  4. dNon-alcoholic steatohepatitis
  5. eNon-alcoholic fatty liver disease
  6. fPrimary biliary cirrhosis
  7. gAutoimmune hepatitis
  8. hHepatitis C Virus
  9. iReverse transcriptase polymerase chain reaction
  10. jIsolation by size of epithelial tumor cells